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. 2019 Dec 20;36(1):67–75. doi: 10.3904/kjim.2018.290

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Copyright © 2021 The Korean Association of Internal Medicine

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Effect of pretreatment with indomethacin on the gastroprotection of irsogladine maleate (IM) in mice subjected to ethanol/ydrochloric acid (HCl)-induced gastric ulceration. Mice were pretreated with IM (10 mg/kg), indomethacin (10 mg/kg), misoprostol (100 mg/kg, orally) or combination of indomethacin and misoprostol or IM. Sixty minutes after, gastric mucosal lesions were induced with ethanol/HCl (20 mL, orally) in all groups. Each value represents the mean ± SD of the percentage of ulcerated gastric area (n = 6/group).