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. 2021 Jan 8;11:599564. doi: 10.3389/fimmu.2020.599564

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Copyright © 2021 Alghamdi, Mulla, Saheb Sharif-Askari, Guzmán-Vega, Arold, Abd-Alwahed, Alharbi, Kashour and Halwani

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relative Gene expression for STING1, IFNα and IFNβ1 for the whole family before treatment. (A) qRT-PCR relative Quantification for Gene Expression for STING1, IFNα and IFNβ1. There is over expression for IFNβ1 in patients compared to non-affected individuals (SEM = 3.4). STING1 and IFNα showed no significant increase in expression in patients compared to non-affected individuals. STING1 (SEM = 0.44) and IFNα (SEM = 3.4). (B) IFN β1 plasma level of the family before treatment.