Table 2.
The GO function enrichment analysis of CXC-chemokines and neighbor genes in HNSCC (Metascape).
| GO | Category | Description | Count | % | Log10(P) | Log10(q) |
|---|---|---|---|---|---|---|
| GO:0008009 | GO Molecular Functions | Chemokine activity | 45 | 68.18 | −100 | −96.43 |
| GO:0002685 | GO Biological Processes | Regulation of leukocyte migration | 26 | 39.39 | −36.95 | −34.15 |
| GO:0006874 | GO Biological Processes | Cellular calcium ion homeostasis | 29 | 43.94 | −31.93 | −29.21 |
| GO:0071222 | GO Biological Processes | Cellular response to lipopolysaccharide | 21 | 31.82 | −27.15 | −24.55 |
| GO:0045236 | GO Molecular Functions | CXCR chemokine receptor binding | 8 | 12.12 | −18.48 | −16.04 |
| GO:2000501 | GO Biological Processes | Regulation of natural killer cell chemotaxis | 7 | 10.61 | −16.53 | −14.1 |
| GO:0008201 | GO Molecular Functions | Heparin binding | 13 | 19.7 | −15.05 | −12.65 |
| GO:0050918 | GO Biological Processes | Positive chemotaxis | 10 | 15.15 | −14.53 | −12.15 |
| GO:0050729 | GO Biological Processes | Positive regulation of inflammatory response | 11 | 16.67 | −12.44 | −10.11 |
| GO:0022407 | GO Biological Processes | Regulation of cell−–cell adhesion | 14 | 21.21 | −11.41 | −9.12 |
| GO:0048514 | GO Biological Processes | Blood vessel morphogenesis | 16 | 24.24 | −10.5 | −8.22 |
| GO:0071677 | GO Biological Processes | Positive regulation of mononuclear cell migration | 6 | 9.09 | −10.37 | −8.1 |
| GO:1903237 | GO Biological Processes | Negative regulation of leukocyte tethering or rolli | 4 | 6.06 | −10.29 | −8.04 |
| GO:0031728 | GO Molecular Functions | CCR3 chemokine receptor binding | 4 | 6.06 | −10.29 | −8.04 |
| GO:0009615 | GO Biological Processes | Response to virus | 12 | 18.18 | −10.1 | −7.85 |
| GO:0071622 | GO Biological Processes | Regulation of granulocyte chemotaxis | 6 | 9.09 | −8.67 | −6.47 |
| GO:0008360 | GO Biological Processes | Regulation of cell shape | 8 | 12.12 | −8.11 | −5.95 |
| GO:0031735 | GO Molecular Functions | CCR10 chemokine receptor binding | 3 | 4.55 | −7.71 | −5.58 |
| GO:0002274 | GO Biological Processes | Myeloid leukocyte activation | 12 | 18.18 | −6.75 | −4.65 |
| GO:0002544 | GO Biological Processes | Chronic inflammatory response | 4 | 6.06 | −6.72 | −4.62 |