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. 2021 Jan 8;10:570736. doi: 10.3389/fonc.2020.570736

Table 2.

The GO function enrichment analysis of CXC-chemokines and neighbor genes in HNSCC (Metascape).

GO Category Description Count % Log10(P) Log10(q)
GO:0008009 GO Molecular Functions Chemokine activity 45 68.18 −100 −96.43
GO:0002685 GO Biological Processes Regulation of leukocyte migration 26 39.39 −36.95 −34.15
GO:0006874 GO Biological Processes Cellular calcium ion homeostasis 29 43.94 −31.93 −29.21
GO:0071222 GO Biological Processes Cellular response to lipopolysaccharide 21 31.82 −27.15 −24.55
GO:0045236 GO Molecular Functions CXCR chemokine receptor binding 8 12.12 −18.48 −16.04
GO:2000501 GO Biological Processes Regulation of natural killer cell chemotaxis 7 10.61 −16.53 −14.1
GO:0008201 GO Molecular Functions Heparin binding 13 19.7 −15.05 −12.65
GO:0050918 GO Biological Processes Positive chemotaxis 10 15.15 −14.53 −12.15
GO:0050729 GO Biological Processes Positive regulation of inflammatory response 11 16.67 −12.44 −10.11
GO:0022407 GO Biological Processes Regulation of cell−–cell adhesion 14 21.21 −11.41 −9.12
GO:0048514 GO Biological Processes Blood vessel morphogenesis 16 24.24 −10.5 −8.22
GO:0071677 GO Biological Processes Positive regulation of mononuclear cell migration 6 9.09 −10.37 −8.1
GO:1903237 GO Biological Processes Negative regulation of leukocyte tethering or rolli 4 6.06 −10.29 −8.04
GO:0031728 GO Molecular Functions CCR3 chemokine receptor binding 4 6.06 −10.29 −8.04
GO:0009615 GO Biological Processes Response to virus 12 18.18 −10.1 −7.85
GO:0071622 GO Biological Processes Regulation of granulocyte chemotaxis 6 9.09 −8.67 −6.47
GO:0008360 GO Biological Processes Regulation of cell shape 8 12.12 −8.11 −5.95
GO:0031735 GO Molecular Functions CCR10 chemokine receptor binding 3 4.55 −7.71 −5.58
GO:0002274 GO Biological Processes Myeloid leukocyte activation 12 18.18 −6.75 −4.65
GO:0002544 GO Biological Processes Chronic inflammatory response 4 6.06 −6.72 −4.62