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Flowchart of trial procedures. All the COVID-19 patients met the inclusion criteria: 1. Age ≥18 years, 2. Positive results of sars-cov-2 by qRT-PCR, 3. PaO2/FiO2 ≤ 200mmHg, 4. Total plasma cortisol was measured. Patients did not receive prolonged hormonal therapy, and do not have hypothalamus, pituitary gland, adrenal gland disease or mental illness; Female patients were not pregnant.
