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. 2021 Jan 8;14:598548. doi: 10.3389/fnins.2020.598548

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Copyright © 2021 McDonough, Elsen, Daza, Bachleda, Pizzo, DelleTorri and Hevner.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tbr2 is required for the differentiation of calretinin⁺ unipolar brush cells. (A,C,E) Calretinin⁺ cells are present in the adult WT cerebellum but missing in the adult Tbr2 cKO cerebellum (B,D,F) at all time points observed suggesting a defect of UBC genesis, differentiation, or migration. In panel (E) the inset shows a close up of Tbr2⁺ (red)/calretinin⁺ (green) UBCs found in the WT cerebellum, a cell type that is missing in the Tbr2 cKO cerebellum. Scale bars: 500 μm in (A,B), 200 μm (C–F).