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. 2021 Jan 8;14:598548. doi: 10.3389/fnins.2020.598548

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Copyright © 2021 McDonough, Elsen, Daza, Bachleda, Pizzo, DelleTorri and Hevner.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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β-gal histochemistry in Tbr2^LacZ/flox cerebellum enables the tracing of putative UBC progenitors in the Tbr2 cKO cerebellum. (A,C) In the WT cerebellum the Tbr2-expressing (β-gal⁺) UBCs are in the granular layer of lobules X and IX in the medial and lateral cerebellum. (B,D) In the Tbr2 cKO cerebellum most β-gal⁺ cells accumulated in posterior lobule X, adjacent to the site of the former rhombic lip (arrow) suggesting a migration defect.