Table 1.

Calculated Absolute Binding Free Energy for Au-Carbene-G-Quadruplex Binding

Contribution	Result [kcal/mol]	Standard Error [kcal/mol]
ΔGbind,restr	−14.9	±0.7
ΔGo,bulk	6.4	N/A
ΔGconf,bulk	3.6	±0.1
−ΔGa,site	−0.6	±0.2
−ΔGo,site	−3.1	±0.6
−ΔGconf,site	−1.8	±0.1
ΔGbind,0	−10.4	±1.0

N/A, not applicable.