TABLE 2.
Purple non-sulfur bacteria as cell factories: the production of heterologous products and overexpression of native products via genetic modification and the production titers thereof.
| Organism | Product | Method | Titer | References |
| Rhodobacter Sphaeroides Rs265 | Amorphadiene | Expression of ads and MVA pathway (mvaA, idi, hcs, mvk, pmk, mvd) (Huembelin et al., 2014) | 46.1 mg/L | Orsi et al., 2020a |
| Coenzyme Q10 | Overexpression of crtE and ppsR Deletion of crtB, crtC, crtD and crtI | 73.2 mg/L | Zhu et al., 2017 | |
| Lycopene | Insertion of crtI4 and dxs Deletion of crtI3, crtC, and zwf | 66.0 mg/L | Su et al., 2018 | |
| Sesquiterpene | Insertion of MVA pathway (mvaA, idi, hcs, mvk, pmk, mvd) (Huembelin et al., 2014) Deletion of dxr | 7.0 mg/L | Orsi et al., 2020b | |
| Valencene | Insertion of CnVS and MVA pathway (mvaA, idi, hcs, mvk, pmk, mvd) (Huembelin et al., 2014) | 0.4 g/L | Beekwilder et al., 2014 | |
| Rhodobacter sphaeroides HY01 | Hydrogen | Overexpression of atp (F1 operon) | 8.5 LH2/L | Zhang et al., 2016a |
| Rhodobacter sphaeroides HJ | Poly(3-hydroxybutyrate) | Insertion of phaA3, phaB2, and phaC1 Deletion of phaZ | 1.9 g/L | Kobayashi and Kondo, 2019 |
| Rhodobacter capsulatus SB1003 | Botryococcene | Insertion of dxs, idi, fps | 0.1 g/L | Khan et al., 2015 |
| Hydrogen | Deletion of mmsa | 4.7 LH2/L | Zhang et al., 2016b | |
| Patchoulol | Insertion of P, ispA, dxs and idi, and MVA pathway (mvaA, idi, hcs, mvk, pmk, mvd) (Huembelin et al., 2014) | 24 mg/L | Troost et al., 2019 | |
| Valencene | Insertion of CnVS, ispA, and MVA pathway (mvaA, idi, hcs, mvk, pmk, mvd) (Huembelin et al., 2014) | 18 mg/L | Troost et al., 2019 | |
| Rhodopseudomonas palustris TIE-1 | Squalene | Expression of dxs and a fused crtE-hpnD Deletion of shc | 15.8 mg/g DCW | Xu et al., 2016 |
| Rhodopseudomonas palustris CGMCC 1.2180 | Methane | Mutation of nifD at V75A and H201Q | 144 nmol/mg total protein | Ma et al., 2020 |
| Rhodopseudomonas palustris CGA009 | Butanol | Insertion of adhE2 | 0.1 g/L | Doud et al., 2017 |
| Hydrogen | Expression of nifA Deletion of draT2 | 1.3 LH2/L | Wu et al., 2016 | |
| Rhodopseudomonas palustris CEA1001 | Canthaxanthin | Insertion of crtY, and crtW Deletion of crtC and crtD | 0.8 mg/L | Giraud et al., 2018 |
| β-carotene | Insertion of crtY, and crtW Deletion of crtC and crtD | 4.7 mg/L | Giraud et al., 2018 | |
| Lycopene | Deletion of crtC and crtD | 7.2 mg/L | Giraud et al., 2018 | |
| Rhodospirillum rubrum S1 | Lycopene | Deletion of crtC and crtD | 15 mg/L | Wang et al., 2012 |