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. 2021 Jan 8;8:575029. doi: 10.3389/fpubh.2020.575029

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Copyright © 2021 Priori, Baisi, Banderali, Biglioli, Bulfamante, Canevini, Cariati, Carugo, Cattaneo, Cerri, Chiumello, Colosio, Cozzolino, D'Arminio Monforte, Felisati, Ferrari, Gambini, Gardinali, Marconi, Olivari, Orfeo, Opocher, Pietrogrande, Previtera, Rossetti, Vegni, Toschi, Zuin and Centanni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunohistochemical positivity for SARS-CoV-2 in autoptical tissues. Immunohistochemistry examination was performed using an automated immunostainer (DAKO OMNIS). (A) Brain. The red granule in the cytoplasm of neurons (arrows) and glial cells (arrowheads) indicates the positivity for nuclear protein (NP) of the virus. (B) Lung. Widespread cellular positivity (brown granulia) for viral spike protein. Positive cells are largely macrophages and pneumocytes. [A: SARS-CoV-2 (2019-nCoV) Nucleoprotein/NP Antibody, Rabbit MAb; Sino Biological; 1:800, antigen retrieval low; detection with DAB. B: SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [1A9] Cat No. GTX632604; GeneTex; 1:100, antigen retrieval high; detection with Magenta].