Table 2.

Gene set analysis tools

Tool	Author	Year	Citations	Availability	Gene sets	Methods
WEBGESTALT	Zhang et al. [73]	2005	1423	Web server	GO, KEGG, +20 more	ORA, GSEA
GOSTATS	Falcon and Gentleman [74]	2007	1437	R package	GO	ORA
G:PROFILER	Reimand et al. [75]	2007	534	Web server	GO, KEGG, +7 more	ORA
GENETRAIL	Backes et al. [76]	2007	360	Web server	GO, KEGG, +28 more	ORA, GSEA
DAVID	Huang et al. [8]	2009	19 569	Web server	GO, KEGG, +38 more	ORA
GORILLA	Eden et al. [77]	2009	1881	Web server	GO	ORA
TOPPGENE	Chen et al. [78]	2009	1200	Web server	GO, KEGG, +45 more	ORA
CLUSTER-PROFILER	Yu et al. [10]	2012	1305	R package	GO, KEGG, +8 more	ORA, GSEA
PANTHER	Mi et al. [79]	2013	1405	Web server	GO, +2 more	ORA, GSEA
ENRICHR	Chen et al. [9]	2013	1246	Web server	GO, KEGG, +33 more	ORA

¹Google Scholar, July 2019.

²Detailed summary of implemented methods in Supplementary Methods S1.2.