Table 2.
Comparison of different parameters of the whole-volume ADC histogram in the breast cancers with low and high TIL levels.
| Variable | Low TIL levels (n=66) | High TIL levels (n=48) | t value | P-value |
|---|---|---|---|---|
|
Mean ADC
(×10−6 mm2/s) |
1,112.06 ± 191.90 | 1,190.90 ± 235.35 | −1.968 | 0.052 |
| 10th percentile ADC (×10−6 mm2/s) | 784.38 ± 190.18 | 870.42 ± 161.03 | −2.541 | 0.012 |
| 25th percentile ADC (×10−6 mm2/s) | 916.68 ± 181.05 | 994.79 ± 184.92 | −2.254 | 0.027 |
| 50th percentile ADC (×10−6 mm2/s) | 1,081.42 ± 192.56 | 1,156.60 ± 241.09 | −1.850 | 0.078 |
| 75th percentile ADC (×10−6 mm2/s) | 1,283.09 ± 225.82 | 1,356.63 ± 316.97 | −1.374 | 0.173 |
| 90th percentile ADC (×10−6 mm2/s) | 1,494.08 ± 284.80 | 1,571.52 ± 340.96 | −1.319 | 0.190 |
| skewness | 0.45 ± 0.60 | 0.61 ± 0.64 | −1.357 | 0.178 |
| entropy | 6.73 ± 1.42 | 6.84 ± 1.38 | −0.414 | 0.679 |
| kurtosis | 1.22 ± 1.53 | 1.81 ± 1.89 | −1.848 | 0.067 |
The 10th, 25th, and 50th percentile ADC values, kurtosis and mean ADC were significantly higher in the luminal subtype than in the non-luminal subtype of breast cancer (P<0.001, P=0.002, P=0.025, P=0.007 and P=0.013). Significant differences were found in the above ADC histogram parameters among different molecular subtypes of breast cancer ( Table 3 ).