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. 2021 Jan 8;11:600635. doi: 10.3389/fimmu.2020.600635

Figure 1.

Figure 1

Macrophages accumulate in the peripheral areas of the liver lesions of patients with AE. (A) Representative H&E and immunohistochemistry staining for the general macrophage marker CD68, the anti-inflammatory macrophage marker CD163 and the proinflammatory macrophage marker S100A9 in paired liver tissue samples (DLT versus CLT) from patients with AE (scale bar, 200μm for 100× magnification; 50 μm for 400× magnification). The lesion is delimited with a black line. (B–E) The percentage of positively stained areas was calculated to assess the expression of CD68, CD163, and S100A9. Close (CLT): “close” liver tissue was approximately 0.5 cm from the lesion (i.e., metacestode); distant (DLT): “distant” liver tissue was at least 2 cm from the lesion. The results are presented as the mean ± SEM (n = 15). ***p < 0.001, ****p < 0.0001.