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. 2021 Jan 8;11:585361. doi: 10.3389/fimmu.2020.585361

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Copyright © 2021 Varghese, Murugaiah, Beirag, Temperton, Khan, Alrokayan, Al-Ahdal, Nal, Al-Mohanna, Sim and Kishore

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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C4BP modulates viral entry in a strain-dependent manner. Luciferase reporter activity of C4BP treated MDCK cells infected with matched H1+N1 and unmatched H3+N2 lentiviral pseudo-particles. H1N1 particles exhibited a 55% decrease in viral entry compared to controls, while a 17% increase in viral entry in case of H3N2 was observed. Results are normalized against cells infected with the particles not treated with C4BP. Significance was determined using the unpaired one-way ANOVA test (****p < 0.0001) (n = 3).