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Main mechanisms used to target cellulose REGs (1): Ligation of hydrazine analogues (NH2‐NH‐R) or hydroxylamine derivatives (NH2‐O‐R) affording hydrazones or oximes (2); reductive amination forming an imine intermediary (3) that is reduced to a stabilized secondary amine (4); Pinnick oxidation affording carboxylated REGs (5) that allow for subsequent amidation (6); Knoevenagel condensation affording a C‐glycoside ketone (7).
