Figure 2. Change in Log Viral Load and in Viral Load Cycle Threshold Over Time With Bamlanivimab Monotherapy and Bamlanivimab and Etesevimab Combination Therapy.

Randomization and infusion occurred on day 1. A, The middle line represents the median change from baseline for log viral load; the boxes represent the interquartile range; the squares inside each box represent the mean; the whiskers extend to the highest and lowest values within 1.5 x the interquartile range of the nearer quartile; and the dots represent observed values outside that range. B, The cycle threshold is defined as the number of cycles required for the fluorescent signal of the polymerase chain reaction assay to cross the threshold (ie, exceeds background level). Cycle threshold levels are inversely proportional to the number of copies of the virus and thus serve to estimate viral load. Virus is presumed to be undetectable beyond approximately 40 cycle thresholds. SARS-CoV-2 indicates severe acute respiratory syndrome coronavirus 2.