TABLE 3.
Normal and pathological mitochondria in neurons of REF and IIH subjects
| REF (n = 9) | IIH (n = 8) | Significance | |
|---|---|---|---|
| Neuronal soma | |||
| Normal mitochondria | |||
| Number of normal mitochondria per soma (n) | 50.8 ± 31.2 | 37.1 ± 26.7 | t(14) = 0.921, p = 0.373 |
| Area of normal mitochondria per soma (nm2) | 134,348 ± 28,130 | 148,286 ± 81,386 | t(14) = 0.482, p = 0.637 |
| Pathological mitochondria | |||
| Number of pathological mitochondria per soma (n) | 8.8 ± 11.2 | 20.5 ± 24.1 | t(15) = 1.313, p = 0.209 |
| Area of pathological mitochondria per soma (nm2) | 240,857 ± 85,877 | 179,493 ± 84,110 | t(10) = 1.250, p = 0.240 |
| Presynaptic terminals | |||
| Normal mitochondria | |||
| Number of normal mitochondria per presynaptic terminal (n) | 25.6 ± 16.1 | 19.5 ± 12.8 | t(11) = 0.658, p = 0.524 |
| Area of normal mitochondria per presynaptic terminal (nm2) | 91,017 ± 32,840 | 86,311 ± 18,669 | t(11) = 0.264, p = 0.797 |
| Pathological mitochondria | |||
| Number of pathological mitochondria per presynaptic terminal (n) | 0.1 ± 0.3 | 4.3 ± 4.0 | t(11) = 3.242, p = 0.008 |
| Area of pathological mitochondria per presynaptic terminal (nm2) | 59,537 ± 178,611 | 130,097 ± 46,214 | t(11) = 0.761, p = 0.462 |
| Postsynaptic terminals | |||
| Normal mitochondria | |||
| Number of normal mitochondria per postsynaptic terminal (n) | 6.1 ± 5.6 | 6.0 ± 3.5 | t(11) = 0.036, p = 0.970 |
| Area of normal mitochondria per postsynaptic terminal (nm2) | 160,597 ± 83,189 | 58,612 ± 68,869 | t(11) = 2.134, p = 0.056 |
| Pathological mitochondria | |||
| Number of pathological mitochondria per postsynaptic terminal (n) | 0 | 1.0 ± 1.2 | t(11) = 2.277, p = 0.044 |
| Area of pathological mitochondria per postsynaptic terminal (nm2) | 0 | 166,672 ± 233,199 | t(11) = 2.760, p = 0.019 |
Data presented as mean ± standard deviation (SD). Significant differences between continuous variables were determined by independent samples t test or Mann–Whitney U‐test.