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(A, B) Immunomodulatory effect of metformin and calcineurin inhibitor (CNI) combination treatment in liver transplant patients with diabetes. In all five patients, the population of CD4+Th17 cells were decreased, whereas CD4+Treg and CD8+Treg were increased after addition of metformin (1000 mg/day) treatment (*p < 0.05, **p < 0.01, *** p < 0.005).
