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. 2021 Jan 8;11:606268. doi: 10.3389/fimmu.2020.606268

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Copyright © 2021 Oyelakin, Horeth, Song, Min, Che, Marzullo, Lessard, Rasmussen, Radfar, Scofield, Lewis, Stone, Grundahl, De Rossi, Kurago, Farris, Sivils, Sinha, Kramer and Romano

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gene Networks and Canonical Pathways Generated by Ingenuity Pathway Analysis (IPA). (A) Top 21 significantly affected canonical pathways for DEGs identified in our dataset based on IPA. Bars denote the different pathways based on Z-scores (2.0 < Z score < −2.0). Orange color indicates pathway activation, while blue denotes suppression. (B–D) Gene network analysis using IPA for pathways selected from panel A above. Solid lines denote high correlation between members of a defined cluster and dotted lines denote weak inter-cluster correlation.