Effect of SCARA5 overexpression on carcinogenesis. (A) Subcutaneous tumor volumes in mice injected with SCARA5 overexpression or knockdown cells. **P<0.01, Over-SCARA5 vs. Blank; #P<0.05, sh-SCARA5 vs. Blank. (B) Reverse transcription-quantitative PCR analysis of SCARA5 expression in mice injected with SCARA5 overexpression or knockdown cells. ***P<0.001 vs. Blank, ###P<0.001 vs. Sh-control. (C) Western blot analysis of SCARA5 expression in mice injected with SCARA5 overexpression or knockdown cells. Data are presented as the mean ± SEM (n=3 with three repeats). ***P<0.001 vs. Blank, ###P<0.001 vs. Sh-control. (D) Immunohistochemical analysis of SCARA5 expression in mice injected with SCARA5 overexpression or knockdown cells. (E) Immunohistochemical analysis of Ki67-positive cells and TUNEL-positive cells in mice injected with SCARA5 overexpression or knockdown cells. Scale bar, 100 µm. SCARA5, scavenger receptor class A member 5; sh, short hairpin RNA; NC, negative control.