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. 2021 Jan 13;23(3):201. doi: 10.3892/mmr.2021.11840

Figure 3.

Figure 3.

Effects of NAC on oxidative stress, p-Akt/p-eNOS protein expression and serum NO levels in diabetic ApoE−/− mice fed a HLD. (A) Aortic protein expression of GSH, MG, protein carbonyl contents and serum MDA levels (n=5 repeats/group). (B) Aortic protein expression levels of antioxidant enzymes (SOD-1 and GPX-1) (n=4 repeats/group). (C) Aortic protein expression levels of p-Akt and p-eNOS (n=4 repeats/group). (D) Serum levels of NO (n=4 repeats/group) in ApoE−/− mice (Con group), STZ-injected ApoE−/− mice (DM group), STZ-injected ApoE−/− mice fed a HLD (DM + HLD group), and STZ-injected ApoE−/− mice fed a HLD and administered NAC-containing water (DM + HLD + NAC group). *P<0.05 vs. Con group; #P<0.05 vs. DM group; &P<0.05 vs. DM + HLD group. ApoE, apolipoprotein E; Con, control; DM, diabetes mellitus; HLD, high-lipid diet; NAC, N-acetylcysteine; STZ, streptozotocin; GSH, glutathione; MG, methylglyoxal; p-, phosphorylated; eNOS, endothelial nitric oxide synthase; NO, nitric oxide.