Table I.

Abnormal expression and pathogenic mechanism of Munc18-1 in different neurological disorders.

First author, year	Neurological disorders	Munc18-1 expression	Pathogenic mechanism	(Refs.)
Romaniello et al, 2015; Ortega-Moreno et al, 2016; Miyamoto et al, 2017	Epileptic encephalopathy	Decreased	GABA-ergic disorder Impaired synaptic plasticity	(17,43,73)
Toonen et al, 2006	Autism	Decreased	Glutamatergic and GABA-ergic disorder Neurodevelopmental disorders	(71)
Ramos-Miguel et al, 2015 Behan et al, 2009 Urigüen et al, 2013	Schizophrenia	Increased	Dopaminergic disorder	(19,46,75)
Lanoue et al, 2019	Parkinsons disease	Decreased	Regulates α-synaptic protein replication and aggregation Impaired synaptic plasticity	(78)
Ramos-Miguel et al, 2015	Alzheimers disease	Decreased	Highly phosphorylated Tau protein Impaired synaptic plasticity GABA-ergic disorder	(82)
Linker et al, 2009	Multiple sclerosis	Increased	Glutamate excitotoxicity	(48)
Murphy et al, 2015	Duchennes muscular dystrophy	Decreased	Unclear	(49)
Sleat et al, 2017	Neuronal ceroid lipofuscinosis	Decreased	Unclear	(50)

GABA, γ-aminobutyric acid.