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R7W-MP corrects the reduced interaction between mutant Cavα1.2 and Cavβ2. Cavβ2-Cavα1.2 protein affinity as measured in a BRET assay in HEK293 cells transfected with Cavβ2-NanoLuc and Cavα1.2-Halo (WT, T320M, and Q428E mutant) and treated with increasing doses (0.12, 1.3, and 10.2 μM) of R7W-MP and R7W-Scr as indicated (n = 6). * p < 0.05; ** p < 0.01 (Mann-Whitney test). Black, red, and blue indicate untreated conditions.
