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. 2021 Jan 8;10:585551. doi: 10.3389/fonc.2020.585551

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Copyright © 2021 Morris, Wages, Grant, Stukenberg, Gentzler, Hall, Akerley, Varghese, Arnold, Williams, Coppola, Jones, Auble and Mayo

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MYBL2 High lung adenocarcinoma patient identification. (A) A 15 gene panel reliably identified MYBL2 High lung adenocarcinoma across TCGA and ORIEN cohorts. (B) MYBL2 High (N = 82) tumors significantly overexpress RAD51 (T-test, two-sided), XRCC1 (T-test, two-sided), and FOXM1 (T-test, two-sided) proteins, compared to MYBL2 Low (N = 91). MYBL2 High tumors also exhibit significantly decreased expression of NKX2-1 protein (T-test, two-sided), a key marker of lung differentiation.