Table 2.
Unadjusted and multivariable-adjusted HRs for incidence of AF comparing people with and without diabetes by sex, and hazard ratio for women relative to men
Number | Person-time | Number of patients with AF during FU | Incidence rate (95% CI) | Hazard ratio (95% CI) | Women-to-men ratio (95% CI) | ||||
---|---|---|---|---|---|---|---|---|---|
Diabetes vs no diabetes | (HR in women/HR in men) | ||||||||
Unadjusted | Adjusted | Unadjusted | Adjusted | ||||||
Women | |||||||||
No diabetes | 1,416,545 | 6,855,046.80 | 114 855 | 1.68 (1.67–1.69) | |||||
Type 1 diabetes | 21,440 | 97,121.95 | 2 557 | 2.63 (2.53–2.74) | 1.50 (1.44–1.56) | 1.32 (1.27–1.37) | |||
Type 2 diabetes | 158,536 | 697,591.24 | 23,556 | 3.38 (3.33–3.42) | 1.93 (1.90–1.96) | 1.17 (1.16–1.19) | |||
1.35 (1.28–1.42) | 1.18 (1.12–1.24) | for type 1 diabetes | |||||||
1.20 (1.18–1.22) | 1.10 (1.08–1.12) | for type 2 diabetes | |||||||
Men | |||||||||
No diabetes | 1,113 974 | 4 971 106.10 | 145 269 | 2.92 (2.91–2.94) | |||||
Type 1 diabetes | 23,949 | 103,232.26 | 3 474 | 3.37 (3.26–3.48) | 1.12 (1.09–1.16) | 1.12 (1.08–1.16) | |||
Type 2 diabetes | 186,963 | 751,998.44 | 37,301 | 4.96 (4.91–5.01) | 1.64 (1.62–1.65) | 1.10 (1.09–1.12) |
Adjusted for age at inclusion and baseline characteristics (among smoking, obesity, hypertension, hypercholesterolemia, alcohol abuse, previous stroke, and non-cardiovascular comorbidities). Women to men ratio > 1 indicates an excess risk for incident AF in women with prevalent type 1 or type 2 diabetes mellitus compared with men with prevalent similar type of diabetes mellitus
HR hazard ratio, WMR women-to-men ratios