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The DDX18→microRNA-21→PTEN/AKT pathway. (A, B) DDX18 affects the PTEN/AKT signaling pathway by controlling the maturation of microRNA-21. (C) DDX18 can also affect the expression of PTEN by regulating microRNA-21, which in turn affects the phosphorylation of AKT and regulates the AKT signaling pathway. (D–G) DDX18 interference strongly inhibited the AGS cell subcutaneous tumorigenic ability in vivo. *P < 0.05, ***P < 0001.
