. 2021 Jan 22;21:45. doi: 10.1186/s12872-021-01857-2

Table 3.

Associations between lymphocyte subsets (per 1-SD) and average systolic blood pressure level (mmHG) across 10 years of follow-up

	∆ mmHG (per SD)	95% CI lower	95% CI upper	p value
Primary hypotheses (significance threshold p < 0.0125)
Th1	1.19	− 0.41	2.79	0.15
Th17	− 0.06	− 1.31	1.18	0.92
Tregs	1.09	0.05	2.13	0.04
γδ T	2.40	1.34	3.42	< 0.0001
Exploratory hypotheses (significance threshold p < 0.0017)
T cells	− 1.22	− 2.34	− 0.09	0.03
B cells	− 0.45	− 1.6	0.7	0.44
NK cells	1.88	0.82	2.94	0.0005
Classical monocytes	− 2.01	− 3.24	− 0.79	0.0013
Intermediate monocytes	0.98	− 0.31	2.28	0.14
Non-classical monocytes	1.82	0.64	3.00	0.0025
CD4⁺	− 0.15	− 1.19	0.89	0.78
Th2	− 0.14	− 1.45	1.18	0.84
Naïve CD4⁺	0.18	− 0.97	1.34	0.76
Memory CD4⁺	0.49	− 0.68	1.65	0.41
CD4⁺ CD28⁻	− 0.19	− 1.34	0.96	0.75
CD4⁺ CD28⁻ CD57⁺	− 0.04	− 1.17	1.08	0.94
CD4⁺ T_EMRA	0.45	− 0.53	1.43	0.37
CD4⁺ CD38⁺	− 0.36	− 1.51	0.80	0.54
CD4⁺ CD57⁺	0.05	− 1.07	1.17	0.93
CD8⁺	0.11	− 1.02	1.24	0.85
Tc1	1.24	− 0.11	2.59	0.07
Tc2	− 0.93	− 2.21	0.34	0.15
Tc17	0.49	− 0.90	1.88	0.49
Naïve CD8⁺	0.97	− 0.15	2.09	0.09
Memory CD8⁺	− 1.02	− 2.13	0.09	0.07
CD8⁺ CD28⁻	0.91	− 0.28	2.09	0.13
CD8⁺ CD28⁻ CD57⁺	0.69	− 0.46	1.84	0.24
CD8⁺ T_EMRA	0.99	− 0.13	2.12	0.08
CD8⁺ CD38⁺	0.53	− 0.58	1.64	0.35
CD8⁺ CD57⁺	0.42	− 0.67	1.52	0.45

Statistical models are linear mixed models using repeated blood pressure measures for MESA exams 1–5, and adjusted for baseline age, sex, race/ethnicity, smoking, exercise, body mass index, college education, diabetes, and log transformed CMV antibody titer