Table 2.
Clinical characteristics of the patients with OPSCC
| All patients (n = 80) |
HPV-related (n = 25) |
HPV-unrelated (n = 55) |
P-value | |
|---|---|---|---|---|
| Sex | 0.595 | |||
| Male | 61 | 20 (80.0) | 41 (74.5) | |
| Female | 19 | 5 (20.0) | 14 (25.5) | |
| Age (years) | 0.513 | |||
| 63.2 ± 10.2 | 62.0 ± 8.9 | 63.7 ± 10.9 | ||
| T | 0.009 | |||
| T1, T2 | 36 | 16 (64.0) | 18 (32.7) | |
| T3, T4 | 49 | 9 (36.0) | 37 (67.3) | |
| N | 0.14 | |||
| N0, N1 | 33 | 7 (28.0) | 25 (45.4) | |
| N2, N3 | 52 | 18 (72.0) | 30 (54.6) | |
| M | 0.459 | |||
| M0 | 76 | 25 (100) | 51 (92.7) | |
| M1 | 2 | 0 (0) | 2 (7.3) | |
| SCC differentiation | 0.103 | |||
| Well | 22 | 5 (20.0) | 17 (30.9) | |
| Moderately | 42 | 11 (44.0) | 31 (56.4) | |
| Poorly | 8 | 5 (20.0) | 3 (5.4) | |
| Unknown | 8 | 4 (16.0) | 4 (7.3) | |
| Tumor subsite | 0.134 | |||
| Lateral | 59 | 22 (88.0) | 37 (67.3) | |
| Anterior | 19 | 3 (12.0) | 16 (29.1) | |
| Superior | 2 | 0 (0) | 2 (3.6) | |
| Primary treatment | 0.012 | |||
| Surgery ± RT/CCRT CCRT to Surgery | 23 | 3 (12.0) | 20 (36.4) | |
| RT or CCRT | 52 | 22 (88.0) | 30 (54.5) | |
| No treatment | 5 | 0 (0) | 5 (9.1) | |
| 5-year overall survival (%) | 73.7 | 95.8 | 63.2 | 0.024 |
CCRT Concurrent chemoradiotherapy, RT Radiotherapy, SCC Squamous cell cancer