Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jan 22;12:77. doi: 10.1186/s13287-021-02156-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 6 — Mechanism analysis of doxorubicin-induced hUC-MSCs apoptosis. a Top 20 enriched pathways predicted by KOBAS based on the discrepancy of miRNA in Blank and Dox groups, which are related to the cytotoxicity of doxorubicin. b Top 20 enriched pathways predicted by KOBAS based on the discrepancy of miRNA in Dox and EV groups, which are related to the therapeutic potential of hP-MSC-derived extracellular vesicles for doxorubicin cytotoxicity. c The binding sites and match diagram between hsa-miR-11401 and SCOTIN are presented, and the expression of hsa-miR-11401 and SCOTIN among groups was further verified. The hsa-miR-11401 facilitated the downregulation of SCOTIN in EV groups. n = 3, ^*P < 0.05 versus Blank groups; ^#P < 0.05 versus Dox groups. d The expression of hsa-miR-11401 in extracellular vesicles showed that it can be delivered into recipient cells. n = 3,^*P < 0.05 versus MSC