Table 4.
Diagnostic accuracy of PET/MRI and MRI for the detection of local tumor invasion and lymph node metastasis on a regional level
| Regions | PET/MRI | MRI | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sens | Spec | Acc | PPV | NPV | AUC (95% CI) | Sens | Spec | Acc | PPV | NPV | AUC (95% CI) | |
| Local invasion | ||||||||||||
| Deep stromal a (positive 9/20) | 100% | 91% | 95% | 90% | 100% | 0.96 (0.85–1.00) | 89% | 60% | 74% | 67% | 86% | 0.74 (0.51–0.98) |
| Vaginal (positive 12/33) | 75% | 95% | 88% | 90% | 87% | 0.85 (0.69–1.00) | 100% | 48% | 67% | 52% | 100% | 0.74 (0.57–0.91) |
| Parametrial (positive 10/33) | 90% | 87% | 88% | 75% | 95% | 0.89 (0.75–1.00) | 100% | 46% | 63% | 46% | 100% | 0.73 (0.56–0.90) |
| Lymph node metastasis | ||||||||||||
| Pelvic right (LNM in 12/33) | 67% | 91% | 82% | 80% | 83% | 0.79 (0.61–0.97) | 75% | 71% | 73% | 60% | 83% | 0.73 (0.55–0.92) |
| Pelvic left (LNM in 12/33) | 42% | 91% | 73% | 71% | 73% | 0.66 (0.46–0.87) | 58% | 91% | 79% | 78% | 79% | 0.74 (0.55–0.94) |
| Para-aortic (LNM in 4/33) | 50% | 100% | 94% | 100% | 94% | 0.75 (0.43–1.00) | 50% | 96% | 91% | 67% | 93% | 0.73 (0.41–1.00) |
Sens sensitivity, Spec specificity, Acc accuracy, PPV positive predictive value, NPV negative predictive value, AUC area under the curve, CI confidence interval, LNM lymph node metastasis
a ≥ 50% of the cervical stroma thickness; evaluated only in patients with histological reference