Table 3.

Associations of IFNL3/IFNL4 polymorphisms with spontaneous HCV clearance in HD patients exposed to HCV

Gene†	rs no.	HCV RNA positive			HCV RNA negative			A difference in genotype/allele distribution between HCV RNA positive and HCV RNA negative			The probability of spontaneous HCV clearance in the dominant mode of inheritance‡		The probability of spontaneous HCV clearance in the additive mode of inheritance§
		n	Genotype distribution, n (frequency)	MAF	n	Genotype distribution, n (frequency)	MAF	P trend¶	P genotype∆	P allelic∆	OR, 95% CI	P value∆, sample power	OR, 95% CI	P value∆, sample power
IFNL3	12980275	91	AA 25 (27.5) AG 48 (52.7) GG 18 (19.8)	0.46	68	AA 35 (51.5) AG 26 (38.2) GG 7 (10.3)	0.29	0.003	0.007	0.002	2.8, 1.45–5.43	0.002 97%	3.60, 1.31–9.91	0.011 > 99.9%
IFNL3	4803217	92	GG 29 (31.5) GT 48 (52.2) TT 15 (16.3)	0.42	67	GG 36 (53.7) GT 27 (40.3) TT 4 (6.0)	0.26	0.002	0.01	0.003	2.52, 1.32–4.84	0.005 95%	4.66, 1.39–15.56	0.008 > 99.9%
IFNL4	12979860	90	CC 29 (32.2) CT 45 (50.0) TT 16 (17.8)	0.43	67	CC 36 (53.7) CT 26 (38.8) TT 5 (7.5)	0.27	0.004	0.015	0.004	2.44, 1.27–4.69	0.007 93%	3.97, 1.30–12.14	0.012 > 99.9%
IFNL4	368234815	93	TT/TT 29 (31.2) TT/∆G 49 (52.7) ∆G/∆G 15 (16.1)	0.42	68	TT/TT 37 (54.4) TT/∆G 28 (41.2) ∆G/∆G 3 (4.4)	0.25	0.0009	0.004	0.001	2.63, 1.38–5.04	0.003 97%	6.38, 1.69–24.2	0.003 > 99.9%
IFNL4	8099917	92	TT 48 (52.2) GT 38 (41.3) GG 6 (6.5)	0.27	68	TT 51 (75) GT 17 (25) GG 0 (0)	0.13	0.001	0.003#	0.001	2.75, 1.39–5.45	0.003 98%	13.8, 0.76–251.6	0.027# > 99.9%

† − chromosomal localization of IFNL3 and IFNL4 genes towards the forward strand is shown

‡ − genotypes with the variant alleles as reference

§ – the variant homozygosity as reference

¶ - Cochran-Armitage Trend Test

∆ - Pearson’s Chi-squared test

# - Fisher’s exact test