Table 4.
Frequencies of IFNL3 and IFNL4 haplotypes concerning spontaneous HCV elimination (cases) and persistent HCV infection (controls)
SNPs | Haplotype | Haplotype Frequencies | Case, Control Frequencies |
Chi Square | P Value | Pcorr Value† |
OR (95%CI)‡, P Value | OR (95%CI)§, P Value |
---|---|---|---|---|---|---|---|---|
rs12980275_rs4803217_rs12979860_rs368234815_rs8099917 | A_C_C_TT_T | 0.562 | 0.667, 0.485 | 10.590 | 0.0011 | 0.0060 | 2.294 (1.412–3.727), 0.0007 | Reference |
G_A_T_∆G_G | 0.174 | 0.102, 0.227 | 8.543 | 0.0035 | 0.0190 | 0.380 (0.197–0.732), 0.0030 | 0.326 (0.167–0.638), 0.0008 | |
G_A_T_∆G_T | 0.121 | 0.110, 0.130 | 0.289 | 0.5909 | 1.0000 | 0.819 (0.411–1.632), 0.5692 | 0.611 (0.301–1.241), 0.1706 | |
G_C_C_TT_T | 0.043 | 0.037, 0.046 | 0.164 | 0.6855 | 1.0000 | 0.736 (0.241–2.253), 0.5901 | 0.543 (0.175–1.685), 0.2847 | |
A_A_T_∆G_T | 0.020 | 0.008, 0.028 | 1.583 | 0.2083 | 0.7840 | 0.263 (0.030–2.280), 0.1934 | 0.196 (0.022–1.709), 0.1024 | |
G_A_T_TT_G | 0.016 | 0.015, 0.016 | 0.013 | 0.9081 | 1.0000 | 0.894 (0.147–5.434), 0.9032 | 0.652 (0.106–3.997), 0.6415 |
†P-value calculated using the permutation test and a total of 1000 permutations
‡All other haplotypes pooled together were used as the reference
§The most common haplotype was used as the reference