Figure 2.

AG490 regulated the phosphorylation of JAK2/3 and STAT3. (a). AG490 regulated the phosphorylation of JAK2/3 and STAT3 determined by Western blot in the treatment of NC or AG490. (b). The fold change analysis of (a). (c). Protein expressions of apoptosis‐related proteins of Annexin V, Bax, Bcl‐2, and cleaved caspase‐3 in the treatment of NC or AG490. (d). The fold change analysis of (c). (e). mRNA expressions of JAK2 in sham mice or I/R mice. Unpaired t test was utilized for the comparison between the NC and the AG490. *p < .05, **p < .01, ***p < .001 compared with NC. The experiment was repeated three times independently