. 2021 Jan 8;11:616020. doi: 10.3389/fimmu.2020.616020

Table 1.

Antigen presenting cells in the gut.

	Location	Human	Mouse
cDC1	MLN	Resident: HLA-DR^int CD11c^hi CD11b⁻ CD8α⁺ XCR1⁺ SIRPα⁻CD141⁺ DNGR1⁺ Migratory: HLA-DR^hi CD11c^int CD103⁺ CD11b⁻ XCR1⁺ SIRPα⁻CD141⁺ DNGR1⁺	Resident: MHC-II^int CD11c^hiCD11b⁻ CD8α⁺ XCR1⁺ SIRPα⁻ DNGR1⁺ Migratory: MHC-II^hi CD11c^int CD103⁺ CD11b⁻ XCR1⁺ SIRPα⁻ DNGR1⁺
	LP	CD103⁺ CD11b⁻ XCR1⁺ SIRPα⁻CD141⁺ DNGR1⁺	CD103⁺ CD11b⁻ XCR1⁺ SIRPα⁻ DNGR1⁺
	PP	CD103⁺ CD11b⁻ CD8α⁺ XCR1⁺ SIRPα⁻CD141⁺ DNGR1⁺	CD103⁺ CD11b⁻ CD8α⁺ XCR1⁺ SIRPα⁻ DNGR1⁺
cDC2	MLN	Resident: HLA-DR^int CD11c^hi CD103⁺ CD11b⁺ XCR1⁻CD1c⁺ SIRPα⁺ CD141⁻ DNGR1⁻ Migratory: HLA-DR^hi CD11c^int CD103⁺ CD11b⁺ XCR1⁻CD1c⁺ SIRPα⁺ CD141⁻ DNGR1⁻	Resident: MHC-II^int CD11c^hi CD103⁺ CD11b⁺ XCR1⁻ SIRPα⁺ Migratory: MHC-II^hi CD11c^int CD103⁺ CD11b⁺ XCR1⁻ SIRPα⁺
	LP	1.CD103⁺ CD11b⁺ XCR1⁻CD1c⁺ SIRPα⁺ CD141⁻ DNGR1⁻ 2. CD103^- CD11b⁺ XCR1⁻CD1c⁺ SIRPα⁺ CD141⁻ DNGR1⁻	1.CD103⁺ CD11b⁺ XCR1⁻ SIRPα⁺ 2.CD103^- CD11b⁺ XCR1⁻ SIRPα⁺
	PP	HLA-DR⁺ CD11C⁺ CD1c⁺(?) XCR1^-	CD103^- CD11b⁺ XCR1⁻ SIRPα⁺
pDC	MLN, LP, PP	CD11c⁻ CD123⁺ BDCA2⁺(?) BDCA4⁺(?)	CD11c^midB220⁺ PDCA1⁺ LY6C⁺CCR9⁺ Siglec-H⁺
Monocyte	MLN, LP, PP	Classical: CCR2^hiM-CSFR⁺ CD14^hiCD11b⁺ non-classical monocytes: CCR2^low M-CSFR⁺ CD14^low	Classical: CCR2^hiM-CSFR⁺ Ly6C^hi non-classical monocytes: CCR2^low M-CSFR⁺ Ly6C^low
monocyte-derived cells	MLN, LP, PP	CD14^⁺ CD11b⁺SIRPα⁺ /CD172⁺BDCA1/CD1c⁺CD226⁺	CD209a⁺ CD11b⁺ CD64⁺CCR2⁺ Ly6C⁺ CD88⁺ SIRPα⁺ /CD172⁺CX3CR1^mid
Macrophage	MLN, LP, PP	HLA-DR⁺ CD68⁺ CD64⁺ CD209⁺ MerTK⁺ CD14⁺ CD206⁺CD163⁺	CX3CR1^hi CD11b⁺CD64⁺ F4/80⁺MerTK⁺ SIRPα⁺ CD163⁺

Commonly used markers for defining APC subsets in the gut of humans or mice are summarized based on location and subset. “?” indicates that well-accepted markers have not yet been established.