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. 2021 Jan 8;11:579907. doi: 10.3389/fimmu.2020.579907

Figure 6.

Figure 6

Leptospiral Immunoglobulin-Like B (LigB) Domains Involved in Interactions with Host Proteins. Regions of LigA and LigB involved in interactions with host proteins are shown for heparin (73), C4 binding protein (C4BP) (73), tropoelastin (56), factor XIII (91), fibrinogen (6, 92), laminin (90), collagen III (6), complement components C3b and C4b (71), the gelatin-binding domain (GBD) of fibronectin (53), the amino-terminal domain (NTD) of fibronectin (32, 93), the 70 kDa fragment of fibronectin (6), and the 15th type III module of fibronectin (15F3) (55). The color scheme used for the Lig proteins is identical to that of Figure 1 . Nearly identical sequences between LigA and LigB are shown in yellow. The remaining Big_2 domains are shown in green (LigA) and blue (LigB). The C-terminal extensions (CTE) contain putative Big_5 domains (dashed). Black bars indicate high-affinity binding (< 100 nM) to the host target, gray bars indicate moderate affinity (100–800 nM), and open bars indicate low affinity (> 1 µM).