Fig. 2.

Co-expression of CXCR3/CCR5, CCR3/CCR4, and CD161/CCR6 on CD4⁺ T lymphocytes. Percentage rates of CXCR3/CCR5, CCR3/CCR4, and CD161/CCR6 co-expression on CD4⁺ T lymphocytes in the peripheral blood (PB), synovial fluid (SF), and synovial membrane (SM) of patients with early knee OA are shown. Surface marker expression was analyzed by flow cytometry, and the results are presented as a percentage of total CD4⁺ T cells. Data is shown as mean (SEM) (n = 12 paired samples). Significant differences between SF/PB and SM/PB are marked with asterisks (*); significant differences between SF/SM are marked with a hash (^#): *p < 0.05; **p < 0.01; ***p < 0.001; ^#p < 0.05