Table 2.
Clinical profile and CCTA findings associated with major cardiovascular events
| Univariable HR (95% CI) | P-value | Multivariable HR (95% CI)a | P-value | |
|---|---|---|---|---|
| Age (years) | 1.04 (1.03–1.05) | <0.001 | 1.03 (1.01–1.04) | <0.001 |
| Male gender | 0.94 (0.78–1.13) | 0.938 | ||
| BMI (kg/m2) | 1.03 (1.01–1.05) | 0.003 | 1.01 (0.98–1.03) | 0.506 |
| Chest pain symptoms | ||||
| No chest pain | Reference | |||
| Non-anginal | 1.03 (0.74–1.44) | 0.864 | ||
| Atypical | 0.84 (0.65–1.08) | 0.170 | ||
| Typical | 1.21 (0.85–1.72) | 0.284 | ||
| Cardiovascular risk factors | ||||
| Diabetes | 1.90 (1.51–2.38) | <0.001 | 1.59 (1.16–2.18) | 0.004 |
| Hypertension | 1.60 (1.33–1.93) | <0.001 | 1.33 (1.02–1.73) | 0.038 |
| Hypercholesterolaemia | 0.97 (0.81–1.17) | 0.769 | ||
| Family history of CAD | 1.01 (0.82–1.23) | 0.945 | ||
| Current smoker | 1.12 (0.89–1.40) | 0.338 | ||
| CCTA findings | ||||
| Segment involvement score | 1.18 (1.14–1.22) | <0.001 | ||
| 0 | Reference | |||
| 1 | 1.77 (1.35–2.30) | <0.001 | 1.89 (1.32–2.71) | 0.001 |
| 2–3 | 2.53 (1.99–3.21) | <0.001 | 2.48 (1.76–3.47) | <0.001 |
| 4–5 | 3.09 (2.26–4.22) | <0.001 | 2.54 (1.64–3.95) | <0.001 |
| >5 | 3.68 (2.66–5.09) | <0.001 | 3.08 (1.98–4.81) | <0.001 |
| Diseased segments | ||||
| Left main | 1.80 (1.41–2.29) | <0.001 | ||
| Proximal LAD | 2.06 (1.71–2.49) | <0.001 | ||
| Proximal RCA | 1.98 (1.60–2.50) | <0.001 | ||
| Proximal LCX | 2.40 (1.92–2.98) | <0.001 |
a
Adjusted for statin and/or aspirin use and early revascularization. CAD, coronary artery disease; CCTA, coronary computed tomography angiography; LAD, left anterior descending artery; LCX, left circumflex; LM, left main; RCA, right coronary artery.