Table 3.
Interactions between clinical variables and presence or absence of CAD
| No CAD |
Non-obstructive CAD |
P-interaction | |||
|---|---|---|---|---|---|
| Univariable HR (95% CI) | P-value | Univariable HR (95% CI) | P-value | ||
| Age (years) | 1.02 (1.01–1.04) | 0.003 | 1.03 (1.02–1.05) | <0.001 | 0.182 |
| Male gender | 0.88 (0.64–1.21) | 0.425 | 0.82 (0.65–1.03) | 0.085 | 0.715 |
| BMI (kg/m2) | 1.04 (1.00–1.08) | 0.061 | 1.02 (1.00–1.04) | 0.052 | 0.477 |
| Chest pain symptoms | 0.110 | ||||
| No chest pain | Reference | Reference | |||
| Non-anginal | 1.39 (0.78–2.47) | 0.270 | 0.87 (0.58–1.31) | 0.511 | |
| Atypical | 0.77 (0.48–1.25) | 0.289 | 0.93 (0.69–1.26) | 0.636 | |
| Typical | 0.80 (0.39–1.65) | 0.551 | 1.67 (1.12–2.49) | 0.012 | |
| Cardiovascular risk factors | |||||
| Diabetes | 1.07 (0.66–1.73) | 0.783 | 2.35 (1.82–3.04) | <0.001 | 0.004 |
| Hypertension | 1.61 (1.16–2.22) | 0.004 | 1.38 (1.10–1.75) | 0.006 | 0.486 |
| Hypercholesterolaemia | 0.83 (0.60–1.16) | 0.277 | 0.87 (0.69–1.08) | 0.203 | 0.807 |
| Family history of CAD | 0.92 (0.64–1.32) | 0.655 | 1.10 (0.86–1.40) | 0.467 | 0.447 |
| Current smoker | 1.02 (0.67–1.54) | 0.939 | 1.12 (0.85–1.46) | 0.428 | 0.763 |
CAD, coronary artery disease; CCTA, coronary computed tomography angiography; LAD, left anterior descending artery; LCX, left circumflex; LM, left main; RCA, right coronary artery.