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. 2021 Jan 8;11:607166. doi: 10.3389/fimmu.2020.607166

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Copyright © 2021 Wetterö, von Löhneysen, Cobar, Kristenson, Garvin and Sjöwall

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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C-reactive protein (CRP) levels in morning and evening saliva samples. Displayed are absolute CRP levels (A) and CRP levels relative to the total protein concentrations (B). Related morning and evening absolute CRP concentrations (C) and percentages (D) are shown for each participant. Morning CRP levels were classified as low (≤1.3 ng/ml) and high (>1.3 ng/ml) concentrations, respectively, and each group was compared to the related evening values. Given are the results for absolute CRP (E) and CRP percentages of total protein (F). Differences in morning and evening levels of the same day were identified by Wilcoxon tests. Box plots reflect the IQR with the median shown as a line and the 5^th–95^th percentiles as bars. Significant differences are highlighted by ** p<0.01 (n.s., not significant).