Table 2.
Estimates of treatment and prophylactic failure of sulphadoxine-pyrimethamine among antenatal care attendees in Nchelenge District, Zambia
| Category | Number of women | Proportion of parasite-positive women at day 28, % (n) | 95% Confidence intervals |
|---|---|---|---|
| Overall parasitological and prophylactic failurea | 590 | 18.6 (109) | 15.5, 21.8 |
| Total prophylactic failureb | 411 | 18.3 (75) | 14.8, 22.3 |
| Day 0 malaria positives | |||
| Day 28 PCR uncorrected parasitological failure | 207 | 30.0 (62) | 23.7, 36.2 |
| Day 28 PCR corrected parasitological failure | 205c | 15.6 (32) | 11.2, 21.3 |
| Day 28 PCR corrected reinfection | 60 | 46.7 (28) | 34.2, 59.6 |
| Day 0 malaria negatives | |||
| Day 28 PCR uncorrected prophylactic failure | 383 | 12.3 (47) | 9.0, 15.6 |
PCR polymerase chain reaction diagnostic methods
aAll positives among women who took SP at enrolment and tested malaria positive at day 28 which includes prophylactic and parasitological failures
bThe total includes aparasitaemic at day 0 and parasitaemic at day 28 plus the 28 women who were parasitaemic at day 0 and day 28 due to reinfection
cTwo samples could not be differentiated between recrudescence or reinfection, which is reflected in the smaller denominator (205) of samples after PCR correction for parasitological failure