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. 2021 Jan 22;9:6. doi: 10.1186/s40170-021-00240-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Sirt6 heterozygous deletion increases tumor latency and enhances survival in the MMTV-PyMT mammary tumor model. a Tumor masses were excised from MMTV-PyMT^+/−; Sirt6^+/+ and MMTV-PyMT^+/−; Sirt6^+/− mice; protein lysates were generated, and Sirt6 and vinculin levels were detected by Western blot. b Tumor latency (upper panel) and overall survival (lower panel) of MMTV-PyMT^+/−; Sirt6^+/+ (n = 39) and of MMTV-PyMT^+/−; Sirt6^+/− (n = 30) mice were monitored over time. c Histopathological analysis of the mammary glands from MMTV-PyMT^+/−; Sirt6^+/+ and MMTV-PyMT^+/−; Sirt6^+/− mice (hematoxylin-eosin; × 40 and × 400) shows poorly differentiated (G3) murine ductal carcinoma of the breast consisting in dysmetrical elements with solid growth, brisk mitotic activity, and scattered areas of necrosis in both types of tumor. d Mammary glands from 4-week-old MMTV-PyMT^+/−; Sirt6^+/+ (n = 3) and MMTV-PyMT^+/−; Sirt6^+/− (n = 3) mice were stained by carmine alum (left) and used to quantify the TEB (right). LN, lymph node. Data are presented as mean ± SD; ns, not statistically significant. e Blood glucose levels in Sirt6^+/+ (n = 6), Sirt6^+/− (n = 3), MMTV-PyMT^+/−; Sirt6^+/+ (n = 3), and MMTV-PyMT^+/−; Sirt6^+/− (n = 6) mice. Data are presented as mean ± SD. ns, not statistically significant