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. 2021 Jan 19;9:e10711. doi: 10.7717/peerj.10711

Figure 3. Distribution of variants according to ACMG guidelines among all classes of 307 genetic variants.

Figure 3

Class I (highest pathogenic potential) variants were predicted disease causing by at least 7 of the tools, class II (intermediate pathogenic potential) variants were predicted disease causing by 4–6 of the tools, class III (low pathogenic potential) were predicted disease causing by 1–3 prediction tools, and class IV (benign) was predicted disease causing by none of the tools (0). The ACMG/AMP classification: P, pathogenic; LP, likely pathogenic; VUS, variant of uncertain significance; LB, likely benign and B, benign.