Figure 4. Distribution of variants (class I+class II) according to their molecular function/association.

The genes were grouped into seven categories using information from GeneCardsR and The Human Gene Database https://www.genecards.org/ (cell membrane, cytoskeleton, sarcomere, metabolism, intercalated disc, ion flux, and nucleus) based on their molecular function and/or subcellular association. Combined mutations of class I and class II were included. Class I (highest pathogenic potential) variants were predicted disease causing by at least 7 of the tools, class II (intermediate pathogenic potential) variants were predicted disease causing by 4–6 of the tools. CHD, coronary heart disease; DCM, dilated cardiomyopathy; iVT, idiopathic ventricular tachycardia; VT, ventricular tachycardia.