Table 1.

Some important factors involved in pyroptosis and their crosstalk pathways.

	Effects	Crosstalk pathways	Reference
IL-1	Recruit inflammatory cells to agglomerate and expand inflammatory response	NLRP3 mRNA/NLRP3/IL-1β pathway MAPK/p38/Smad pathway JNK/NF-κB pathway	Elshaier AM et al. (114)
IL-18	Recruit inflammatory cells to agglomerate and expand inflammatory response	TLR4/MyD88/NF-κB pathway	Liu DW et al. (115)
NLRP3	Identify pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs), recruit and activate caspase-1, promote the maturation and secretion of multiple pro-inflammatory cytokines	NLRP3/Caspase-1/IL-1β(IL-18) pathway Wnt/β-catenin pathway ROS/MAPKs/NF-κB/NLRP3 pathway	Xu LJ et al. (113) Yoshida et al. (108) An YN et al. (116)
Gasdermin-D	Induce cell membrane perforation, cell rupture, release of contents, cause inflammatory response	Caspase-1/GSDMD pathway Caspase-4,5,11/GSDMD pathway	Ran S et al. (109)
Caspase-1	Cut the precursors of Gasdermin D, IL-1β and IL-18	Caspase-1/GSDMD pathway NLRP3/Caspase-1/IL-1β(IL-18) pathway	Xu LJ et al. (113) Ran S et al. (109)
TLR	Receiving, identifying and transmitting signals	TLR4/JNK/NF-κB pathway Wnt/β-catenin pathway	Pei JP et al. (117)