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. 2020 Dec 4;6(49):eabc6983. doi: 10.1126/sciadv.abc6983

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Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 5 — (A) Scheme illustrating that intracallosal stimulation and recording are performed in the ipsi- and contralateral hemisphere, respectively. (B) N1 latency was measured following stimulation in different groups of Shi/Shi:Rag2^−/−: intact or grafted with control or MS-hiOLs and WT mice at 16 wpg. MS-hiOL–derived myelin significantly restored transcallosal conduction latency in Shi/Shi:Rag2^−/− mice to the same extent than control-derived myelin (P = 0.01) and close to that of WT levels. One-way ANOVA with Dunnett’s multiple comparison test for each group against the group of intact Shi/Shi:Rag2^−/− was used. Error bars represent SEMs. *P < 0.05. (C) Representative response profiles for each group. Scales in Y axis is equal to 10 μV and in the X axis is 0.4 ms.