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. 2020 Dec 9;6(50):eabb1654. doi: 10.1126/sciadv.abb1654

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Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 2 — (A) Schematics of the study design. (B) Volcano plot of differentially expressed genes in cf-mRNA between AD (n = 126) and NCI controls of similar age (n = 116). FDR < 0.05 was used as the cutoff criteria. (C) Top 10 significant pathways identified using IPA canonical pathway analysis (top, up-regulated genes in AD; bottom, down-regulated genes in AD). The black vertical dotted line represents P < 0.05. NMF, non-negative matrix factorization; G protein, guanine nucleotide–binding protein; NER, nucleotide excision repair.