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Structure of E. coli DNA gyrase (Protein Data Bank (PDB) entry: 6RKW [23]). The two GyrA subunits are in gray, and the binding site of GyrA/ParC inhibitor ciprofloxacin is represented by the upper black dashed rectangle. The two GyrB subunits are in yellow, and the binding site of GyrB/ParE inhibitors 1a and 1b is represented by the lower black dashed rectangle. The general structure of GyrA/ParC and GyrB/ParE inhibitor hybrids is shown in the middle.
