Table 4.

Minimum inhibitory concentrations of these new hybrid compounds against the three indicated E. coli MG1655 strains. The assays were carried out in the presence of 50 µg/mL PAβN.

Cpd.	Minimum Inhibitory Concentration [µg/mL]
	E. coli MG1655 WT 1	E. coli MG1655 GyrB R136C	E. coli MG1655 GyrA S83L, D87N ParC S80I, E84G
3a	0.5	0.5	16
	(0.73 µM)	(0.73 µM)	(23.4 µM)
3b	64	32	>64
	(81.0 µM)	(40.5 µM)	(>81.0 µM)
7a	1	2	0.5
	(1.35 µM)	(2.70 µM)	(0.675 µM)
7b	1	1	1
	(1.325 µM)	(1.325 µM)	(1.325 µM)
11a	0.5	0.5	8
	(0.65 µM)	(0.65 µM)	(10.4 µM)
11b	1	2	4
	(1.14 µM)	(2.28 µM)	(4.56 µM)
CP 2	<0.03125	<0.03125	64
	(<0.0943 µM)	(<0.0943 µM)	(193 µM)

¹ WT, wild type; ² CP, ciprofloxacin.