Table 8.

In vitro studies on exosomes encapsulated curcumin effect in cancer.

Disease	Exosomes Origin	Exosomes Target	Outcomes	Ref.
Pancreatic cancer	PANC-1 cells, MIA PaCa-2 cells	PANC-1 cells MIA PaCa-2 cells	Cell death induction	[239]
Lung, breast, and cervical cancers	Raw bovine milk	H1299, A549 lung cancer cells MDA-MB-231, T47D breast cancer cells, HeLa cervical cancer cells	Antiproliferative, anti-inflammatory, and antitumor activities	[227]
Breast cancer	TS/A, 4T.1, B16 tumor cells	Murine mammary adenocarcinoma of spontaneous BALB/c origin	Anticancer properties by inhibition of NK cell activity	[240]
Lung cancer	H1299	TCF21, BEAS-2B, A549, PC9, H1299Mouse lung cancer cells	Anti-cancer function by downregulating DNMT1, thereby upregulating TCF21	[241]
Chronic myelogenous leukemia	K562, LAMA84	CML mouse model	Cur-Exo containing miR-21 indicated an antineoplastic effect in chronic myeloid leukemia	[242]
Chronic myelogenous leukemia	K562, LAMA84	CML mouse model	Angiogenic effect	[243,244]
Lymphoma Mammary gland cancer, Colon cancer	Grapefruit	HUVEC/human and T-lymphoma EL4 cells, 4T1 and 4TO7 breast cancer cell lines, NMuMG mammary gland epithelial cells, CT26 colon cancer/mouse	Inhibition of breast tumor and colon tumor growth	[245]