Table 4.
Antiproliferative activity of I13 compared with SAHA (IC50, μMa).
| Cell line | Tumour type | I13 | SAHA |
|---|---|---|---|
| A549 | Lung cancer | 3.15 | 1.73 |
| Calu-3 | Lung cancer | 1.26 | 3.18 |
| SPC-A-1 | Lung cancer | 0.81 | 1.11 |
| H322 | Lung cancer | 14.90 | 73.97 |
| H1299 | Lung cancer | 7.67 | 4.57 |
| MDA-MB-231 | Breast carcinoma | 0.78 | 1.11 |
| MCF-7 | Breast carcinoma | 6.34 | 2.78 |
| MDA-MB-468 | Breast carcinoma | 1.34 | 1.44 |
| LoVo | Colon carcinoma | 2.19 | 1.07 |
| Colo205 | Colon carcinoma | 2.42 | 2.01 |
| A2780 | Ovarian cancer | 4.60 | 27.3 |
| SKOV3 | Ovarian cancer | 1.44 | 1.73 |
| MKN45 | Gastric cancer | 18.19 | 16.06 |
| PNAC-1 | Pancreatic cancer | 1.17 | 6.57 |
| K562 | Leukemia | 2.87 | 4.32 |
| OPM2 | Multiple myeloma | 0.23 | 0.56 |
a
Each value is the mean of at least three experiments.