Table 1.
Radiosensitization by YTR107 and ABT 888.
| Treatment | Survival (±SD) | Radiation Enhancement Ratio | P Value | Fa | Combination Index |
|---|---|---|---|---|---|
| None | 1.0a (0.10) | ||||
| YTR107 alone | 0.48a (±0.08) | ||||
| ABT 888 alone | 0.83a (±0.09) | ||||
| YTR107+ ABT 888 | 0.24a (±0.10) | ||||
| 4 Gy | 0.33a (±0.03) | 0.67 | |||
| YTR107 +4 Gy | 0.192 (±0.03) | 0.81 | |||
| ABT888 +4 Gy | 0.142 (±0.02) | 0.86 | |||
| YTR107+ ABT888 +4 Gy | 0.0432 (±0.01) | 7.67 | P < 0.01 | 0.96 | 0.00029 |
A549 cells in full growth medium (10% FBS) were exposed to YTR107 (25 μM), ABT888 (10 μM) or both YTR107 and ABT888 for 30 min prior to, during irradiation (4 Gy), and for 90 min after irradiation. Cells were washed extensively, incubated in full growth medium supplemented with ABT888 (10 μM) for 70 h, washed again, and allowed to form colonies (>50 cells per colony) in full growth medium. The data presented in the Table represent results averaged from two experiments.
a
Survival corrected for plating efficiency.